With the support of the theme of "Research on key technologies of high performance chemical storage batteries and demonstration power plants" in Advanced Energy Technology Project during the "12th Five-Year Plan" period of 863 Plan, "Research on key technologies of new ultracapacitors with high specific energy and low cost," " Lithium manganate storage battery key technologies and Demonstration "and other topics have made significant progress, recently passed the technical acceptance. According to the Ministry of Science and Technology microblogging "sharp science and technology" August 15 news, in the "new supercapacitor", breaking the bottleneck of high energy density and high power density long-life supercapacitor preparation technology developed porous graphene, high voltage electrolyte Salt and electrolyte, cellulose membrane and other materials, the company developed the dry-preparation electrode plate pilot technology and broke through the core technology of (3.0V / 12000F) supercapacitor industrialization. The products have been applied in mechanical energy recovery and supercapacitor rail vehicles Access to applications at home and abroad. Currently in the super capacitor from materials, devices to system integration has formed a core technology system, changing the super capacitor in the 11th Five-Year monopoly by foreign products situation. In the "long-life lithium manganate storage battery", carried out the layered lithium manganese oxide, lithium manganese oxide coated with lithium cobalt oxide, aluminum cobalt co-doped lithium manganese oxide cathode material, asphalt and resin-derived hard carbon anode Materials and functional electrolytes, as well as the study of single cells, modules and energy storage systems, and mastered the key industrialization technology of long-life and low-cost lithium ion energy storage systems. The life span of single cells has exceeded 3000 times and the maximum reaches 6000 times . In the international community for the first time has become two sets of 50kW / 100kWh layered lithium manganate / hard carbon lithium-ion battery energy storage system development and demonstration operation; also developed 20kWh household solar energy storage system, 3kWh standby emergency power supply and other applications demonstration. In the "all-solid-state lithium ion energy storage battery," Li2S-P2S5 binary system and Li2S-GeS2-P2S5 ternary solid electrolyte with high conductivity have been successfully developed, and the preparation of Li2S-P2S5 system glass ceramic solid electrolyte material has been mastered Method, the preparation of amorphous precursors made a major breakthrough to achieve a high efficiency and stable preparation. Kilo-scale manufacturing capabilities of sulfide solid electrolytes have now been achieved. A high-nickel layered cathode material with core-shell structure and composition gradient was developed. Using the binary sulfide solid electrolyte and the positive electrode, a solid state lithium battery with capacities of 4.0Ah and 8.0Ah was developed and the number of cycles was 500 cycles at room temperature. The assembly process of large all-solid-state flexible battery was optimized and the all-solid state Industrialization process of lithium ion battery. In the "new lithium-sulfur chemical storage battery", the development of high-energy density lithium-sulfur battery technology, developed 35Ah lithium-sulfur battery than the energy to 566Wh / kg (25 ℃ test), reached the world's leading level. Initially developed 1kWh lithium-sulfur battery pack and 12kWh high-capacity lithium-sulfur battery pack, to achieve its coupled with the solar cell demonstration. The use of sulfur-based high-capacity lithium-sulfur battery and battery technology products have the potential for use as long-haul UAV airborne energy systems and other fields, the promotion of broad application prospects. In addition, in the "low-cost lithium titanate-based energy storage lithium-ion battery", opened up low-cost materials mass production, long life and high consistency of batteries and modules, power plant demonstration and promotion of the whole industry chain, built based on lithium titanate Anode material mobile energy storage demonstration device, a 0.5MWh / 1MW lithium titanate battery storage power station demonstration of optical storage, lithium titanate storage for energy storage applications laid the foundation. The project implementation to a certain extent, to meet the large-scale renewable energy and smart grid energy storage needs, and promote the orderly development of wind energy, solar energy and rational allocation of resources to improve the intermittent new energy grid-connected technology, Provide a relatively complete technical support system for China's energy storage battery material-battery-integration-demonstration industry chain, and build an internationally competitive industrialization platform for the sustainable development of the industry in the future, which has promoted the development of China's energy storage industry , Which has strengthened the strategic position of China's energy sustainable development and has broad market prospects. Pyrimidine series intermediates
Pyrimidine, also known as 1,3-diazepine, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by replacing 2 carbons in the meta-position of benzene with 2 nitrogen atoms, and is a diazine. Like pyridine, pyrimidine retains its aromaticity.
Introduction
Name: Pyrimidine
Molecular formula: C4H4N2
Molar mass: 80.09 g/mol
Density: 1.016 g/ml
Melting point: 20 - 22 °C
Boiling point: 123 - 124 °C
CAS Number: 289-95-2
EINECS Number: 206-026-0
SMILES: C1=NC=NC=C1
Application
(1) Anticancer drugs. In the selection of anticancer substances, it is crucial that there are significant differences between tumor tissues and normal tissues, that is, they have a certain ability to recognize target cells. Porphyrin compounds have special affinity for cancer cells due to their unique structures, and they can selectively stay in cancer tissues. The research of it as a localizing agent and a drug for diagnosis and treatment of cancer has already aroused great interest of chemists, medical scientists and biologists. 5-Fluorouracil is a widely used anti-metabolite and anti-tumor drug in clinic. It has inhibitory effect on various tumors. It has good clinical effect in the treatment of colorectal cancer, gastric cancer, breast cancer and other cancers. Polyesters, polyester hydrocarbons, polyester amides, deoxyribonucleic acid, furans, 5-fluorouracil derivatives linked to nitroxide radicals all have antitumor effects.
(2) Anti-AIDS drugs. Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern. There are many kinds of anti-AIDS drugs that have been approved by the US Food Administration (FDA), many of which are nucleoside compounds. In order to reduce the toxicity of drugs and improve their efficacy, scientists have begun to turn their attention to the study of non-nucleoside compounds, and such compounds have become the focus of antiviral drug research.
Synthetic method
Pyrimidines and various substituted pyrimidines are synthesized in a variety of ways. For example, barbituric acid (2,4,6-trihydroxypyrimidine) can be obtained by the condensation of urea and diethyl malonate under the action of sodium alkoxide. Barbituric acid and phosphorus oxychloride are heated together to obtain 2,4,6-trichloropyrimidine, which reacts with sodium methoxide to obtain trimethoxypyrimidine. Chloropyrimidines react with ammonia or primary and secondary amines to generate the corresponding aminopyrimidines. The derivatives of pyrimidine, cytosine, uracil and thymine, are the constituent parts of nucleic acid and deoxynucleic acid, and the pyrimidine part in the vitamin B1 molecule is a 4-amino-2-methyl-5-pyrimidine methyl group. Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.
The 2,4-dichloropyrimidine is prepared by reduction reaction in the presence of palladium, magnesium oxide and activated carbon.
Pyrimidine Series Intermediates,2-Chloro-5-Methylpyrimidine,5-Bromo-2-chloropyrimidine,2 4-Dichloro-5-Methylpyrimidine Fuxin Custchem Fine Chemical Co., Ltd. , https://www.custchemvip.com